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For the second time in six months, ezetimibe Zetia, a featherweight LDL bad cholesterol fighter, has taken a hit, and this blow could well end its career. The referee, with the initials FDA emblazoned on his white lab coat, has begun the countdown. A vigorous advertising campaign resulted in billions of dollars in sales. After five years, except for a decreased number of coronary artery bypasses in the Vytorin group, there were no differences in the incidence of strokes and heart attacks. Also analyzed in that issue of the Journal https://www.kroger.com were two other similar ongoing studies in England.

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Ezetimibe is used alone or in combination with other antilipemic agents i. Efficacy of ezetimibe, alone or in fixed combination with simvastatin, in patients with Fredrickson type I, III, IV, or V dyslipidemias has not been established. Drug therapy is not a substitute for but an adjunct to these https://www.nextavenue.org nondrug therapies and measures, which should be continued when drug therapy is initiated. However, nonstatin drugs may be useful as adjuncts to statin therapy in high-risk patients e. When a nonstatin drug is required, selection of the nonstatin drug should be based on a favorable benefit-risk ratio i.

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We sought to describe the adoption of ezetimibe relative to that of other lipid-lowering agents and compare its use in the two countries. We conducted a population-level, cohort study using data from January to December, provided by IMS Health, to describe prescribing practices and expenditures for lipid-lowering agents and ezetimibe in the United States and Canada.

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